Grapeseed Extract and its benefits.

Grapeseed extract (GSE) is usually extracted naturally from grape seed and it is usually used in dietary supplements for various purposes. It is made by removing, drying, and pulverizing the bitter taste seeds of grape.  It is rich with antioxidant contents such as phenolic acids, anthocyanins, flavonoids, and oligomeric proanthocyanidins complexes (OPC). In fact, grapeseed extract is known as one of the best sources of proanthocyanidins.Due to this there are various benefits of grapeseed extract to human body such as to help prevent disease, to protect against oxidative stress, tissue damages, inflammation and many more. In this article we are going to deep dive into potential health benefits of grapeseed extract (GSE) from studies:
Wound healing activity and antioxidant properties.

Numerous studies have shown that grape seed extract has high level of antioxidants properties. Studies using punctured wounded mice has shown that mice who were treated with GSE in the wound affected area, grow tissue in that area faster than mice who were treated with normal saline only. Another thing noted is that, more organized tissue formation and higher rate of collagen deposition in mice that were treated with GSE as compared to mice with placebo. Topical application of 2% of GSE cream in the area of post-surgery surgical wound also shows to completely heal wound on an average 8 days as compared to placebo which took 14 days for wound healing. It is as so, due to vascular endothelial growth factor (VEGF) properties of GSE which promotes regeneration of the damaged blood vessels and increases the quantity of free radicals present at the wound site. Free radical helps in killing and clearing pathogenic bacteria and endotoxin from the site and helps in curing wound.

Apart from wound healing and skin health properties, it also has anti-ageing properties. Proanthocyanidins in GSE reduce lipid oxidation on the skin structure therefore delay skin ageing.


Cardiovascular and antihypertensive properties.


Cardiovascular disorders (CVD) are among one of the major problems that arises due to the modern and unhealthy lifestyles which results in the primary cause of death worldwide. In general, it refers to the disorder related to the condition and function of heart and blood vessels. Alteration of these two may lead to cardiac arrest, heart stroke, hypertension, chest pain and many more. Studies show that GSE may prevent atherosclerosis (condition where there is build-up of fats, cholesterol, etc in the blood vessels walls which can restrict blood flow), inhibit or limit the oxidation of LDL (bad cholesterol), reducing inflammation, inhibit platelet aggregation, and lower blood pressure. It lowers blood pressure by supressing the oxidative stress, and inhibit the Angiotensin Converting Enzyme (ACE) and nitric oxide mediate vasodilation, hence making the constricted blood vessels dilate and improve blood pressure.


Antimicrobial activity.

GSE has shown that it has effective antimicrobial property against both gram positive ( baccilus cereus, staphylococcus aureus, bacillus coagulans, etc) and gram negative bacteria ( pseudomonal aeruginosa, escherichia coli, etc). GSE contains resevatrol, in which when apply topically it will then increase production of cathelicidin, which inhibits the growth of bacteria.


In conclusions,

GSE has various benefits to health due to its high antioxidant properties, it is able to scavenge the free radicals which an essential feature that could help with various body functions.



  1. National Institute of Health (NIH). National Centre for Complementary and Integrative Health (NICCH). Grape Seed Extract. (Accessed on March 15, 2021)
  2. 10 Benefits of Grape Seed Extract, Based on Science. (Accessed on March 15, 2021).
  3. Gupta, M., Dey, S., Marbaniang, D., Pal, P., Ray, S., & Mazumder, B. (2020). Grape seed extract: Having a potential health benefit. Journal of food science and technology, 57(4), 1205-1215.